Phacilitate Leaders Forum

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Sophia Karagiannis

Sophia Karagiannis

Reader, Translational Cancer Immunology, King’s College London

Dr. Sophia Karagiannis is a Reader in Translational Cancer Immunology at King’s College London. She heads a cancer antibody discovery team focused on designing novel agents for skin, ovarian and breast cancers and striving to understand the cross-talk between patient immune cells and cancer. Major research streams in the Karagiannis laboratory include: a) dissecting B cell and antibody responses and understanding how these are modulated by the tumor microenvironment; b) interrogating patient humoral responses for potential biomarkers to aid stratification and to inform patient-focused treatments; c) designing Fc-modified antibodies with enhanced effector functions; d) elucidating the mechanisms of action of antibodies engineered with modified Fc regions and of different isotypes, namely IgG1, IgG4 and IgE, in disease-relevant models. The group are the first to design and translate an IgE class antibody recognizing a cancer antigen to a Phase I clinical trial in patients with solid tumours.

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    GenSight Biologics
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    Juno Therapeutics, Inc
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    Karnieli Ltd